此清單為微軟發布的「可能在 SP2 環境下出現問題的程式」，非絕對不相容清單。列入軟體可能因 Windows 防火牆、DCOM 權限、資料執行保護 (DEP) 等新安全機制而運作異常。廠商多會釋出修補程式解決。
至微軟知識庫搜尋關鍵字 WINXPSP2 可查詢各軟體具體影響與解決方案。
| 軟體名稱 | 版本 | 廠商 |
|---|---|---|
| Star Trek StarFleet Command III | v1.0 | Activision |
| Medieval Total War | 1 | Activision |
| Pagemaker | 7 | Adobe |
| Photoshop Elements | 2 | Adobe |
| Nero Ultra | 6 | Ahead |
| Nero Burning ROM | 5.5.6 | Ahead |
| AOL | 9 | AOL |
| Unreal Tournament 2003 | 1 | Atari |
| AutoCAD | 2004 | Autodesk |
| StarCraft | 1.05 / 1.11 | Blizzard |
| Warcraft III: Reign of Chaos | v1.0 | Blizzard |
| Command & Conquer: Generals | --- | EA Games |
| SimCity 4 | v1.0 | EA Games |
| Norton AntiVirus | 2003/2004 | Symantec |
| Norton SystemWorks | 2003/2004 | Symantec |
| pcAnywhere | 11 | Symantec |
| McAfee VirusScan | 4.51 | McAfee |
| McAfee Internet Security Suite | 2004 | McAfee |
| ZoneAlarm | 5.0.590 | ZoneLabs |
| Kerio Personal Firewall | 4 | Kerio |
| Style XP | 2 | tgtsoft |
| Microsoft Office | XP/2003 (多版本) | Microsoft |
| Microsoft SQL Server | 7/2000 | Microsoft |
| Visual Studio .NET 2003 | --- | Microsoft |
| RealPlayer (免費版) | 10 | RealNetworks |
| WinZip | --- | --- |
| Yahoo! Messenger | 6.0.0.167 | Yahoo |
微軟官方文件：KB 834373 - Programs that may not work correctly after you install Windows XP Service Pack 2
